Differential Effects of 2 Sea Cucumber Extracts on Caspase Activation and Apoptosis of Human Leukemia Cells

http://www.redorbit.com/media/uploads/2013/03/t-cells-shutterstock_2954130.jpgBoth Frondoside A and Cucumarioside A2-2 are extracts from sea cucumbers.  Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A2-2 is a pentaoside having glucose as a third monosaccahride unit. The effects of Frondoside A and A2-2 for cell death-inducing capability with close attention paid to structure–activity relationships were compared.  Both Frondoside A and A2-2 strongly induced apoptosis of leukemic cells.  Frondoside A-induced apoptosis was more potent and rapid than A2-2-induced apoptosis.  A2-2-induced but not frondoside A-induced apoptosis was caspase-dependent.  This suggests that holothurians may induce apoptosis of leukemic cells caspase-dependently or -independently, depending on the holothurian structure.

Source: https://www.ncbi.nlm.nih.gov/pubmed/19162021

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